At around 7:30 pm officers, Huron County Paramedics and the South Bruce Fire responded to a 2-vehicle collision involving a pickup and SUV on Lucknow Line, just south of Lucknow.
First responders arrived to find two heavily damaged vehicles.
The drivers were both transported to hospital, with one sustaining serious injuries.
Police are seeking any dash-cam footage or video surveillance from the area that may assist in the investigation.
If any witnesses to the collision have not yet come forward they are asked to contact the Huron County OPP or anonymously to Crime Stoppers.